Brixadi vs Sublocade is a common comparison for individuals seeking long-acting treatment for opioid use disorder. Both are FDA-approved buprenorphine injections that reduce cravings and help prevent relapse—but they differ in flexibility, dosing, and how they’re used in recovery. In this article, we’ll break down the key differences between Brixadi and Sublocade to help you make the right choice for your treatment plan.
What Is Brixadi? (Brixadi vs Sublocade)
Brixadi is a long-acting injectable form of buprenorphine used in medication-assisted treatment (MAT) for opioid use disorder. One major advantage of Brixadi in the Brixadi vs Sublocade comparison is that it offers both weekly and monthly doses, making it a flexible option, especially for those just starting recovery.
Key Features:
Active Ingredient: Buprenorphine
Administration: Subcutaneous injection by a healthcare professional
Dosing Frequency: Weekly or Monthly
FDA Approval: Approved in 2023
Brixadi is ideal for patients who are new to treatment and need a weekly option before transitioning to a monthly dose.
What Is Sublocade? (Brixadi vs Sublocade)
Sublocade is also a long-acting buprenorphine injection but is administered monthly only. In the Brixadi vs Sublocade discussion, Sublocade is often seen as a maintenance therapy, suitable for individuals who are already stabilized on oral buprenorphine like Suboxone. It is used after a patient has been stabilized on a lower dose of oral buprenorphine for at least 7 days.
Key Features:
Active Ingredient: Buprenorphine
Administration: Monthly subcutaneous injection
FDA Approval: Approved in 2017
Stabilization Required: Yes, with Suboxone or similar oral buprenorphine
Sublocade is often used in the maintenance phase of opioid addiction treatment, offering convenience and improved medication adherence.
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Buprenorphine injection
How do Brixadi and Sublocade Work?
Both Brixadi and Sublocade work by binding to the same receptors in the brain as opioids. However, they do not produce the same euphoric effects. Instead, they help reduce cravings and manage withdrawal symptoms, making it easier for individuals to abstain from opioid use.
Brixadi and Sublocade contain buprenorphine, a partial opioid agonist. This means that it binds to the opioid receptors in the brain but only activates them partially. As a result, it produces milder effects compared to full opioid agonists like fentanyl, heroin or prescription pain pills like oxycodone.
Both injections release the buprenorphine over a period of time. This formulation is designed to release the medication slowly into the body over the course of a month. By providing continuous relief, Brixadi and Sublocade® help individuals maintain stability in their recovery.
Brixadi vs Sublocade: Key Differences
| Feature | Brixadi | Sublocade |
|---|---|---|
| Dosing Options | Weekly & Monthly | Monthly Only |
| Flexibility | High (ideal for induction phase) | Moderate (maintenance use only) |
| Stabilization Needed | No (can be used from Day 1) | Yes (must stabilize on oral first) |
| Injection Site | Abdomen, thigh, upper arm | Abdomen only |
| FDA Approval Date | 2023 | 2017 |
| Use in New Patients | Yes | No (for stabilized patients only) |
Side Effects of Brixadi and Sublocade
Both medications have similar side effects due to their active ingredient—buprenorphine.
Side Effects: Brixadi vs Sublocade
Common Side Effects:
Injection site pain or swelling
Headache
Constipation
Nausea
Fatigue
Sleep disturbances
Rare but Serious Side Effects:
Respiratory depression
Liver issues
Allergic reactions
Always speak to your healthcare provider about possible interactions or complications, especially if you’re taking other medications.
When to Choose Brixadi vs Sublocade
Which One Is Right for You?
Choosing between Brixadi and Sublocade depends on your unique recovery journey. Here are a few factors to consider:
Choose Brixadi if:
You’re just starting MAT and want flexible dosing.
You prefer weekly supervision before moving to a monthly plan.
You need a non-oral option early in treatment.
Choose Sublocade if:
You’ve been stable on Suboxone or another oral buprenorphine.
You want fewer clinic visits (monthly).
You prefer an established, widely-used injectable MAT.
Brixadi vs Sublocade
Is Brixadi more effective than Sublocade?
Both are equally effective when used as directed. Brixadi may be better for patients needing more hands-on care initially.
Can I switch from Sublocade to Brixadi?
Yes, under medical supervision, you can switch based on your treatment progress.
Is Brixadi better than Sublocade?
Not necessarily—Brixadi offers more flexibility, but both are equally effective when used correctly.
Does insurance cover Brixadi or Sublocade?
Most private insurance and Medicaid plans cover both medications. Always verify with your provider and insurer.
Conclusion
Brixadi and Sublocade are powerful tools in the fight against opioid addiction. While both medications offer long-acting relief from cravings and withdrawal, the choice comes down to your individual needs, treatment goals, and where you are in your recovery. Work closely with your addiction specialist to determine the best plan for you.
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