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All kit guides / Natera

Natera

Signatera MRD

Other self-collectKit guide

Signatera blood draw: two 10 mL Streck tubes every draw, plus one 6 mL EDTA tube for the first test, 21 gauge straight needle, room temperature.

View stepsSee mobile phlebotomy

Specimen

Other self-collect

Tubes / kit

Streck cell-free DNA tubes, an EDTA tube for the first test, and return packaging. [S1]

Processing

Invert each tube gently at least 8 times. Do not shake. [S1]

Shipping

Ship with the kit's prepaid materials, as directed in your kit. [S1]

Not a blood draw

Speedy Sticks performs venipuncture (arm blood draws) only. You collect this kit yourself, following the lab's instructions.

Overview

About this kit

Natera runs the Signatera molecular residual disease test. [S1]

Signatera is a personalized ctDNA test. It is built from the patient's tumor tissue, then tracked with repeat blood draws. [S1]

The process

Step by step

  1. 1

    Before the visit

    Prep

    • Fasting rules are not published. Follow the instructions in your kit.
  2. 2

    The draw

    Draw

    • Draw two 10 mL Streck tubes at every draw. [S1]
    • For the first test, also draw one 6 mL EDTA tube. [S1]
    • Fill tubes completely and let each take 60 to 90 seconds. Use a 21 gauge straight needle. [S1]
  3. 3

    Right after collection

    Processing

    • Invert each tube gently at least 8 times. Do not shake. [S1]
    • Keep at 6 to 37 C (43 to 98 F). Do not refrigerate or freeze. [S1]
  4. 4

    Get it to the lab

    Shipping

    • Ship with the kit's prepaid materials, as directed in your kit. [S1]

At a glance

Tube and processing details

Specimen
  • Other self-collect
Tubes and kit contents
  • Streck cell-free DNA tubes, an EDTA tube for the first test, and return packaging. [S1]
Processing
  • Invert each tube gently at least 8 times. Do not shake. [S1]
  • Keep at 6 to 37 C (43 to 98 F). Do not refrigerate or freeze. [S1]
Shipping
  • Ship with the kit's prepaid materials, as directed in your kit. [S1]

Avoid a redraw

Common mistakes

Forgetting the EDTA tube on the first draw. [S1]
Using a butterfly needle. [S1]

Questions

FAQ

How many tubes?

Two Streck tubes, plus one EDTA tube on the first draw. [S1]

Is it refrigerated?

No. [S1]

On this page

  • About this kit
  • Step by step
  • Tube and processing details
  • Common mistakes
  • FAQ
  • Related kits

Self-collection kit

Speedy Sticks only does venipuncture. If your provider also orders a blood draw, see mobile phlebotomy.

Sources

  • [S1] Natera, Signatera blood sample instructions (MLB-10088 Rev01, hosted on Natera's Hungary site)

    signatera.hu/wp-content/uploads/2025/04/recommended-blood-dr

Keep reading

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